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ABSTRACT
Crateva adansonii is a medicinal herb commonly used in parts of Africa becauseof the side effects of Non-Steroidal Anti-inflammatory Drugs (NSAID), like heart diseases and kidney failure. Inflammation is a major public heart issue in the world but treatment is becoming complex because of the side effects of anti-inflammatory pharmaceutical drugs. Hence the need for alternative drug is highly required. This research work investigated the anti-inflammatory activity of dichloromethane fraction of methanol extract of Crateva adansonii stem bark, using rodent model. Adult Swiss albino rats (110-200g) of either sex were randomlydivided into 5 groups of 4 animals each. Groups 2, 3, 4, and 5 received different doses of the extract (300mg, 500mg, 700mg, and 900mg) in 3% v/v tween 80 administered intraperitonally respectively. Control group-1 received volume of 3%v/v tween 80 and standards group received 100mg/kg Ibuprofen. One hour later acute inflammation was induced by injection of 0.1ml of undiluted egg albumin into the sub planter of the right hand paw of rats. The volume of the paw was measured by mercury displacement before and at 0.5, 1, 1.5, 2, 2.5 & 3 hours after egg albumin injection, while the standard was measured at internals of one hour, for up to 4 hours. Edema formation was assessed in terms of the difference in the zero time per volume of the injected pair and its volume at the different time after egg albumin injection. For each dose of extract, percentage inhibition of edema was calculated percentage inhibition. Result show that Crateva adansonii may have anti-inflammatory effects. This finding supports the use stembark of Crateva adansonii in not only traditional medicine for the treatment of inflammation.
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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2. EXTRACTION AND CHARACTERIZATION OF VEGETABLE OIL USING BREAD FRUIT SEED.
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3. PRODUCTION OF STARCH FROM CASSAVA (Maihot esculanta) AND ITS CROSS LINKED DERIVATIVES
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4. EFFECT OF ETHANOLIC EXTRACT OF GONGRONEMA LATIFOLIUM AND ALLIUM SATIVUM ON LIPID PROFILE OF RATS TREATED WITH SODIUM ARSENITE
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5. DETERMINATION OF PHYTIC ACID CONTENT, OXALATE CONTENT, TANNIN CONTENT AND CYANIDE CONTENT IN TEN EDIBLE SEEDS
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6. EFFECTS OF ETHANOL, METHANOL AND N-HEXANE LEAF AND FRUIT EXTRACTS OF Kigelia africana ON SOME OXIDATIVE AND BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED ...
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8. SCREENING SOME MEDICINAL PLANTS AGAINST MOROCCAN WATERMELON MOSAIC VIRUS (MWMV)
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9. ANALYSIS OF SOME MINERAL CONTENTS OF COCONUT WATER
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10. CARDIO PROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTER RAT
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